mRNA Editing

11 mRNA editing

ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components.

Apolipoprotein (apo)B mRNA editing is accomplished by a large multiprotein complex. How these proteins interact to achieve the precise single-nucleotide change induced by this complex remains unclear. We investigated the relationship between altered apoB mRNA editing and changes in editing enzyme components to evaluate their roles in editing regulation. In the mouse fetal small intestine, we fo...

A minimum principle in mRNA editing?

mRNA editing of sequences of many species is analyzed. The nature of the inserted nucleotides and the position of the insertion sites, once fixed the edited peptide chain, are explained by introducing a minimum principle in the framework of the crystal basis model of the genetic code introduced by the authors.

In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex.

Specific apolipoprotein B (apoB) mRNA editing can be performed in vitro on apoB RNA substrates. Native gels and glycerol gradient sedimentation have been used to determine the physical properties of the in vitro editing activity in rat liver cytosolic S100 extracts. ApoB RNA substrates were progressively assembled as 27S complexes for 3 hr with similar kinetics as seen for the accumulation of e...

A minimum principle in mRNA editing of Physarum ?

mRNA editing in three sequences of Physarum polycephalum is analyzed. Once fixed the edited peptide chain, the nature of the inserted nucleotides and the position of the insertion sites are explained by introducing a minimum principle in the framework of the crystal basis model of the genetic code introduced by the authors. PACS number: 87.10.+e, 02.10.-v LAPTH-812/00 physics/0009063 September ...